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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Contact between dendritic cells (DC) and resting T cells is ...

Class:IdSummation:5621583
_displayNameContact between dendritic cells (DC) and resting T cells is ...
_timestamp2014-09-01 09:57:37
created[InstanceEdit:5621584] Garapati, P V, 2014-09-01
literatureReference[LiteratureReference:5607189] C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
[LiteratureReference:5621598] Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
[LiteratureReference:5621565] Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR
textContact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. CD209 binds the intracellular adhesion molecule 3 (ICAM3) with very high affinity. CD209 interacts primarily with the immunoglobulin (Ig)-like second domain of ICAM2 and ICAM3. CD209-ICAM3 interaction mediates clustering of DCs with naive T cells forming a DC-T cell synapse (Geijtenbeek et al. 2000). CD209 binding to ICAM3 is calcium dependent, and CD209 CRD (carbohydrate recognition domain) binds two Ca2+ ions, one essential for tertiary structure and the other for coordinating ligand binding (Feinberg et al. 2001, Svajger et al. 2010).
(summation)[Reaction:5621615] CD209 binds ICAM3 [Homo sapiens]
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