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Details on Person Defective CP does not oxidise Fe2+ to Fe3+

Class:Id	FailedReaction:5621402
_displayName	Defective CP does not oxidise Fe2+ to Fe3+
_doRelease	TRUE
_timestamp	2016-09-23 20:29:49
authored	[InstanceEdit:5621442] Jassal, Bijay, 2014-08-29
catalystActivity	[CatalystActivity:9631863] ferroxidase activity of CP mutants:6xCu2+:SLC40A1 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5621442] Jassal, Bijay, 2014-08-29
disease	[Disease:5623594] aceruloplasminemia
edited	[InstanceEdit:5621442] Jassal, Bijay, 2014-08-29
entityFunctionalStatus	[EntityFunctionalStatus:5621379] loss_of_function of CP mutants:6xCu2+:SLC40A1 [plasma membrane]
input	[SimpleEntity:435347] Fe2+ [extracellular region] [SimpleEntity:435347] Fe2+ [extracellular region] [SimpleEntity:435347] Fe2+ [extracellular region] [SimpleEntity:435347] Fe2+ [extracellular region] [SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:352327] O2 [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:5621420] Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease [LiteratureReference:5621411] Hereditary caeruloplasmin deficiency, dementia and diabetes mellitus [LiteratureReference:5621433] Hereditary ceruloplasmin deficiency with hemosiderosis [LiteratureReference:5621427] Aceruloplasminemia: molecular characterization of this disorder of iron metabolism
modified	[InstanceEdit:5623578] Jassal, Bijay, 2014-09-17 [InstanceEdit:5623756] Jassal, Bijay, 2014-09-19 [InstanceEdit:6789777] Jassal, Bijay, 2015-08-04 [InstanceEdit:6789873] Jassal, Bijay, 2015-08-05 [InstanceEdit:8940224] D'Eustachio, Peter, 2016-09-23 [InstanceEdit:9631717] Wu, G, 2018-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective CP does not oxidise Fe2+ to Fe3+
normalReaction	[Reaction:917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797125] R-HSA-5621402.4
summation	[Summation:5621421] Ceruloplasmin (CP), synthesised in the liver and secreted in...
(hasEvent)	[Pathway:5619060] Defective CP causes aceruloplasminemia (ACERULOP) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778441] Update Tracker - [FailedReaction:5621402] Defective CP does not oxidise Fe2+ to Fe3+ - v68:[addCatalystActivity] [_UpdateTracker:9782212] Update Tracker - [FailedReaction:5621402] Defective CP does not oxidise Fe2+ to Fe3+ - v59:[add_removeLiteratureReference]
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