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Details on Person SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2

Class:Id	Reaction:5621363
_displayName	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
_doRelease	TRUE
_timestamp	2019-02-22 21:19:21
authored	[InstanceEdit:5621479] Garapati, P V, 2014-08-29
catalystActivity	[CatalystActivity:5621361] protein tyrosine kinase activity of pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643739] protein tyrosine kinase activity of pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5621373] Garapati, P V, 2014-08-29
edited	[InstanceEdit:5621479] Garapati, P V, 2014-08-29
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:5621157] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:443435] Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites [LiteratureReference:5607371] Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
modified	[InstanceEdit:5624497] Garapati, P V, 2014-09-29 [InstanceEdit:5663074] Garapati, P V, 2015-01-15 [InstanceEdit:5671870] Garapati, P V, 2015-02-03 [InstanceEdit:5674203] Garapati, P V, 2015-02-11 [InstanceEdit:9638015] Shamovsky, Veronica, 2019-02-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:5621158] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5621356] PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G [Homo sapiens] [Reaction:5621370] SYK autophosphorylates [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014-09-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680121] R-HSA-5621363.4
summation	[Summation:5621364] Activation of SYK triggers multiple cascades, which induces ...
(hasEvent)	[Pathway:5621480] Dectin-2 family [Homo sapiens]
(precedingEvent)	[Reaction:5621347] PLCG2 translocates from cytosol to plasma membrane [Homo sapiens]
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No pathways have been reviewed or authored by SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (5621363)