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Details on Person Phospholipase C-gamma (PLCG) binds to phosphorylated Tyr-348...

Class:IdSummation:5621350
_displayNamePhospholipase C-gamma (PLCG) binds to phosphorylated Tyr-348...
_timestamp2014-08-29 16:19:45
created[InstanceEdit:5621373] Garapati, P V, 2014-08-29
literatureReference[LiteratureReference:2028806] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
[LiteratureReference:5607371] Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
textPhospholipase C-gamma (PLCG) binds to phosphorylated Tyr-348 (Tyr-342 in mouse) and Tyr-352 (Tyr-346 in mouse) in SYK with its C-terminal SH2 domain (Law et al. 1996). PLCG2 functions downstream of CLEC6A/Dectin-2 and triggers cytokine production in response to the infection by Candida albicans. PLCG2 deficiency results in the defective production of NF-kB and significantly reduced production of reactive oxygen species (ROS) following infection (Gorjestani et al. 2011).
(summation)[Reaction:5621346] Plcg1 binds p-Y348,352,525,526-Syk [Mus musculus]
[Reaction:5621356] PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G [Homo sapiens]
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