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Details on Person ubiquitin protein ligase activity

Class:IdGO_MolecularFunction:5618522
_displayNameubiquitin protein ligase activity
_timestamp2017-02-17 19:45:31
accession0061630
created[InstanceEdit:5618474] Weiser, JD
definitionCatalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ecNumber2.3.2.26
2.3.2.27
2.3.2.31
2.3.2.33
2.3.2.36
modified[InstanceEdit:8978155] Weiser, JD
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
nameubiquitin protein ligase activity
referenceDatabase[ReferenceDatabase:1] GO
(activity)[CatalystActivity:173534] ubiquitin protein ligase activity of SMURF [cytosol]
[CatalystActivity:183039] ubiquitin protein ligase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
[CatalystActivity:934571] ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane]
[CatalystActivity:936422] ubiquitin protein ligase activity of unknown ligase [nucleoplasm]
[CatalystActivity:936474] ubiquitin protein ligase activity of RNF216 [cytosol]
[CatalystActivity:990525] ubiquitin protein ligase activity of ITCH [cytosol]
[CatalystActivity:1270442] ubiquitin protein ligase activity of Activated FGFR:p-FRS2:p-CBL:GRB2 [plasma membrane]
[CatalystActivity:1504214] ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]
[CatalystActivity:3322419] ubiquitin protein ligase activity of TLE:XIAP [nucleoplasm]
[CatalystActivity:3640855] ubiquitin protein ligase activity of RibC-AXIN:TNKS:RNF146 [cytosol]
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No pathways have been reviewed or authored by ubiquitin protein ligase activity (5618522)
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