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Details on Person UniProt:O70511-1 Ank3
| Class:Id | ReferenceIsoform:5618423 |
|---|---|
| _chainChangeLog | chain:1-2622 added on Fri February 6 2015 |
| _displayName | UniProt:O70511-1 Ank3 |
| _timestamp | 2026-02-20 21:37:08 |
| chain | chain:1-2622 |
| checksum | A17F304D792333F5 |
| comment | FUNCTION Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (PubMed:21617128).SUBUNIT May be a constituent of a NFASC/NRCAM/ankyrin G complex. Interacts with RHBG. Directly interacts with DMD and betaDAG1; this interaction does not interfere with DMD-binding and is required for DMD and betaDAG1 retention at costameres. Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 7 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). Interacts with PLEC and FLNC (PubMed:21223964). Interacts (via ANK repeats) with IQCJ-SCHIP1; required for IQCJ-SCHIP1 localization at axon initial segments (AIS) and nodes of Ranvier (By similarity). Interacts with SCHIP1 (By similarity). Interacts with KCNA1; this inhibits channel activity (By similarity). Interacts with SCN5A (By similarity). Interacts with PKP2 and GJA1/CX43 (PubMed:21617128). Interacts with PRICKLE2; the interaction is necessary for correct microtubule bundling (PubMed:36083912).SUBUNIT Interacts (via its C-terminal muscle-specific Obscurin/Titin-Binding-related domain sequence) with PLEC and FLNC.INTERACTION When transfected in root dorsal ganglia, predominantly located in the axolemma of the axon proximal segments (PubMed:9744885). Also associated with the plasma membrane in neuron cell bodies, although at a lower level than in the axon proximal segment (PubMed:9744885). Isoform 1 is restricted to the axolemma of the axon proximal segment. Isoforms containing the muscle-specific 76 amino-acid insertion localize to the sarcolemma and on the postsynaptic membrane of neuromuscular junctions (PubMed:11796721).ALTERNATIVE PRODUCTS Expressed in the heart (at protein level) (PubMed:21617128). Expressed in skeletal muscle (at protein level) (PubMed:21223964). Expressed at highest levels in brain and testis, followed by skin, kidney, liver and spleen (PubMed:15953600).TISSUE SPECIFICITY May be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level).TISSUE SPECIFICITY May be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level).TISSUE SPECIFICITY May be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level).TISSUE SPECIFICITY May be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level).TISSUE SPECIFICITY May be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level).TISSUE SPECIFICITY Expressed in skeletal muscle, brain, lung, heart, testes and kidney.MISCELLANEOUS The 76 amino-acid long sequence from Asp-1888 to Val-1963 is encoded by a muscle-specific exon.MISCELLANEOUS The 76 amino-acid long sequence from Asp-1710 to Val-1785 is encoded by a muscle-specific exon.MISCELLANEOUS The 76 amino-acid long sequence from Asp-1077 to Val-1152 is encoded by a muscle-specific exon.MISCELLANEOUS The 76 amino-acid long sequence from Asp-1060 to Val-1135 is encoded by a muscle-specific exon.MISCELLANEOUS The 76 amino-acid long sequence from Asp-881 to Val-956 is encoded by a muscle-specific exon.MISCELLANEOUS The 76 amino-acid long sequence from Asp-864 to Val-939 is encoded by a muscle-specific exon. |
| created | [InstanceEdit:5618415] Weiser, JD |
| description | recommendedName: Ankyrin-3 shortName: ANK-3 alternativeName: Ankyrin-G |
| geneName | Ank3 |
| identifier | O70511 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ANK repeat Cell membrane Cell projection Cytoplasm Cytoskeleton Lysosome Membrane Phosphoprotein Postsynaptic cell membrane Reference proteome Repeat Synapse |
| modified | [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Ank3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ANK3_RAT Q574D7 Q574D8 Q574D9 Q574E0 Q574E2 Q8VDA0 |
| sequenceLength | 2622 |
| species | [Species:48895] Rattus norvegicus |
| variantIdentifier | O70511-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O70511-1 Ank3 (5618423)
