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Details on Person HDAC6 deacetylates microtubules

Class:Id	Reaction:5618331
_displayName	HDAC6 deacetylates microtubules
_doRelease	TRUE
_timestamp	2023-05-15 15:42:12
authored	[InstanceEdit:5617849] Rothfels, Karen, 2014-08-14
catalystActivity	[CatalystActivity:5618332] tubulin deacetylase activity of HDAC6 [cytosol]
catalystActivityReference	[CatalystActivityReference:9835521] tubulin deacetylase activity of HDAC6 [cytosol] HDAC6 is a microtubule-associated deacetylase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5618329] Rothfels, Karen, 2014-08-19
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
input	[Complex:5618327] acetylated microtubule [cytosol] [Homo sapiens] [SimpleEntity:76194] CoA-SH [cytosol]
internalReviewed	[InstanceEdit:9835527] Orlic-Milacic, Marija, 2023-05-15
isChimeric	FALSE
literatureReference	[LiteratureReference:5422978] HDAC6 is a microtubule-associated deacetylase [LiteratureReference:5618308] Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally [LiteratureReference:5618164] A BBSome subunit links ciliogenesis, microtubule stability, and acetylation
modified	[InstanceEdit:5627028] Rothfels, Karen, 2014-10-14 [InstanceEdit:5627213] Rothfels, Karen, 2014-10-16 [InstanceEdit:5627639] Rothfels, Karen, 2014-10-20 [InstanceEdit:5633399] Matthews, Lisa, 2014-10-31 [InstanceEdit:5638036] Rothfels, Karen, 2014-11-13 [InstanceEdit:5638408] Rothfels, Karen, 2014-11-14 [InstanceEdit:8982433] Orlic-Milacic, Marija, 2017-03-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9833619] Rothfels, Karen, 2023-05-01 [InstanceEdit:9835522] Rothfels, Karen, 2023-05-15 [InstanceEdit:9835530] Rothfels, Karen, 2023-05-15
name	HDAC6 deacetylates microtubules
output	[SimpleEntity:76183] Ac-CoA [cytosol] [Complex:9833607] microtubule (no TUBA4B) [cytosol] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2014-12-11
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644634] R-HSA-5618331.3
structureModified	[InstanceEdit:9833619] Rothfels, Karen, 2023-05-01
summation	[Summation:5618330] HDAC6 is a microtubule-associated deacetylase that targets t...
systematicName	HDAC6 deacetylates acetylated microtubule
(hasEvent)	[Pathway:5620920] Cargo trafficking to the periciliary membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9835699] Update Tracker - [Reaction:5618331] HDAC6 deacetylates microtubules - v85:[add_removeOutput] [_UpdateTracker:9964637] Update Tracker - [Reaction:5618331] HDAC6 deacetylates microtubules - v94:[modifyText]
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No pathways have been reviewed or authored by HDAC6 deacetylates microtubules (5618331)