Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person ATAT acetylates microtubules

Class:IdReaction:5618328
_displayNameATAT acetylates microtubules
_doReleaseTRUE
_timestamp2023-05-15 15:41:55
authored[InstanceEdit:5617849] Rothfels, Karen, 2014-08-14
catalystActivity[CatalystActivity:5618326] L-lysine N6-acetyltransferase activity, acting on acetyl phosphate as donor of ATAT [cytosol]
catalystActivityReference[CatalystActivityReference:9835519] lysine N-acetyltransferase activity, acting on acetyl phosphate as donor of ATAT [cytosol] Atomic resolution structure of human α-tubulin acetyltransferase bound to acetyl-CoA
compartment[Compartment:70101] cytosol
created[InstanceEdit:5618325] Rothfels, Karen, 2014-08-19
edited[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
input[SimpleEntity:76183] Ac-CoA [cytosol]
[Complex:9833607] microtubule (no TUBA4B) [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9835527] Orlic-Milacic, Marija, 2023-05-15
isChimericFALSE
literatureReference[LiteratureReference:5618306] MEC-17 is an alpha-tubulin acetyltransferase
[LiteratureReference:5618301] The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation
[LiteratureReference:5618305] ?TAT1 catalyses microtubule acetylation at clathrin-coated pits
[LiteratureReference:5618299] The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia
[LiteratureReference:9835515] Atomic resolution structure of human α-tubulin acetyltransferase bound to acetyl-CoA
[LiteratureReference:5618296] The axonemal microtubules of the Chlamydomonas flagellum differ in tubulin isoform content
[LiteratureReference:5618311] Microtubule acetylation promotes kinesin-1 binding and transport
[LiteratureReference:5618294] Single molecule imaging reveals differences in microtubule track selection between Kinesin motors
[LiteratureReference:5618164] A BBSome subunit links ciliogenesis, microtubule stability, and acetylation
[LiteratureReference:5637918] Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase
modified[InstanceEdit:5627019] Rothfels, Karen, 2014-10-14
[InstanceEdit:5627195] Rothfels, Karen, 2014-10-16
[InstanceEdit:5627621] Rothfels, Karen, 2014-10-20
[InstanceEdit:5633130] Matthews, Lisa, 2014-10-30
[InstanceEdit:5638023] Rothfels, Karen, 2014-11-13
[InstanceEdit:5638383] Rothfels, Karen, 2014-11-14
[InstanceEdit:8982433] Orlic-Milacic, Marija, 2017-03-17
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9833618] Rothfels, Karen, 2023-05-01
[InstanceEdit:9835524] Rothfels, Karen, 2023-05-15
[InstanceEdit:9835529] Rothfels, Karen, 2023-05-15
nameATAT acetylates microtubules
output[Complex:5618327] acetylated microtubule [cytosol] [Homo sapiens]
[SimpleEntity:76194] CoA-SH [cytosol]
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2014-12-11
reviewed[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10
[InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
reviewStatus[ReviewStatus:9821385] four stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644915] R-HSA-5618328.3
structureModified[InstanceEdit:9833618] Rothfels, Karen, 2023-05-01
summation[Summation:5618324] Cilia are enriched in acetylated tubulin, a marker that is a...
systematicNameATAT transfers CH3CO to microtubule to form acetylated microtubule
(hasEvent)[Pathway:5620920] Cargo trafficking to the periciliary membrane [Homo sapiens]
(updatedInstance)[_UpdateTracker:9835717] Update Tracker - [Reaction:5618328] ATAT acetylates microtubules - v85:[addLiteratureReference, add_removeInput, modifyText]
[_UpdateTracker:9964772] Update Tracker - [Reaction:5618328] ATAT acetylates microtubules - v94:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by ATAT acetylates microtubules (5618328)
Follow Reactome