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Details on Person FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein

Class:Id	Reaction:5618073
_displayName	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
_doRelease	TRUE
_timestamp	2017-03-01 16:21:07
authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5618086] Shamovsky, Veronica, 2014-08-18
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
input	[Complex:5618074] HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5618108] FKBP4 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8944723] The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes [LiteratureReference:8944753] A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8941424] Shamovsky, Veronica, 2016-09-30 [InstanceEdit:8948302] Shamovsky, Veronica, 2016-11-12 [InstanceEdit:8979210] Shamovsky, Veronica, 2017-02-22 [InstanceEdit:8981135] Shamovsky, Veronica, 2017-03-01 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
output	[EntityWithAccessionedSequence:5618096] FKBP5 [cytosol] [Homo sapiens] [Complex:5618101] HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein [Homo sapiens] [Reaction:5618105] FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein [Homo sapiens]
regulatedBy	[PositiveRegulation:5618100] Positive regulation by 'SH [cytosol]'
releaseDate	2017-03-27
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8887675] R-HSA-5618073.3
summation	[Summation:8941423] Mass spectrometry analysis showed that FKBP51 (FKBP5) and FK...
(hasEvent)	[Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand [Homo sapiens]
(precedingEvent)	[Reaction:5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) [Homo sapiens] [Reaction:9028629] Mineralocorticoid binds NR3C2 within the HSP90 chaperone complex [Homo sapiens] [Reaction:9028656] Progesterone binds NR3C2 within the HSP90 chaperone complex [Homo sapiens] [Reaction:9605368] NR3C1 agonist binds NR3C1 within the HSP90 chaperone complex [Homo sapiens] [Reaction:9640160] CK2 binds NR3C2 within the HSP90 chaperone complex [Homo sapiens] [Reaction:9677238] Cortisol binds NR3C2 within the HSP90 chaperone complex [Homo sapiens] [Reaction:9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) [Homo sapiens] [Reaction:9725885] P4 bind PGR (in the HSP90 chaperone complex) [Homo sapiens]
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No pathways have been reviewed or authored by FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (5618073)