Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Retinoic acid activates HOXD4 chromatin

Class:IdBlackBoxEvent:5617896
_displayNameRetinoic acid activates HOXD4 chromatin
_doReleaseTRUE
_timestamp2015-11-20 15:11:41
authored[InstanceEdit:5617432] May, Bruce, 2014-08-07
[InstanceEdit:6810137] Rezsohazy, René, 2015-11-15
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5617850] May, Bruce, 2014-08-15
edited[InstanceEdit:5617678] May, Bruce, 2014-08-13
inferredFrom
input[Complex:5617895] RARA,B:RXRA at HOXD4 bivalent chromatin [nucleoplasm] [Homo sapiens]
[Complex:209680] RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:442488] NCOA3 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:3009044] PAX6 [nucleoplasm] [Homo sapiens]
[DefinedSet:5619379] MLL3,4 complex [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5619459] In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer
[LiteratureReference:5619449] Regulation of the human HOXD4 gene by retinoids
[LiteratureReference:5619306] HOXD4 and regulation of the group 4 paralog genes
[LiteratureReference:4687099] A histone H3 lysine 27 demethylase regulates animal posterior development
[LiteratureReference:5619280] Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation
[LiteratureReference:5687948] Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions
modified[InstanceEdit:5619442] May, Bruce, 2014-08-22
[InstanceEdit:5619473] May, Bruce, 2014-08-22
[InstanceEdit:5619517] May, Bruce, 2014-08-25
[InstanceEdit:5620957] May, Bruce, 2014-08-28
[InstanceEdit:5621535] May, Bruce, 2014-08-30
[InstanceEdit:5626881] May, Bruce, 2014-10-11
[InstanceEdit:5690639] May, Bruce, 2015-04-30
[InstanceEdit:5693645] May, Bruce, 2015-05-17
[InstanceEdit:6808659] May, Bruce, 2015-11-08
[InstanceEdit:6810141] May, Bruce, 2015-11-15
[InstanceEdit:6810171] May, Bruce, 2015-11-15
[InstanceEdit:6810187] May, Bruce, 2015-11-16
[InstanceEdit:6810603] Matthews, Lisa, 2015-11-18
[InstanceEdit:6810604] Matthews, Lisa, 2015-11-18
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRetinoic acid activates HOXD4 chromatin
output[Complex:5617861] atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] [Homo sapiens]
[Complex:212285] PRC2 (EZH2) Core [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:442501] NCOR1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:389115] PCGF2 [nucleoplasm] [Homo sapiens]
releaseDate2015-12-15
releaseStatusNEW
reviewed[InstanceEdit:5693642] Blasi, F, 2015-05-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6812567] R-HSA-5617896.2
summation[Summation:5619514] As inferred from mouse embryos, retinoic acid activates the ...
(hasEvent)[Pathway:5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:5617874] HOXD4 gene is transcribed [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Retinoic acid activates HOXD4 chromatin (5617896)
Follow Reactome