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Details on Person Retinoic acid activates HOXB1 chromatin

Class:IdBlackBoxEvent:5617452
_displayNameRetinoic acid activates HOXB1 chromatin
_doReleaseTRUE
_timestamp2015-11-20 15:11:22
authored[InstanceEdit:5617432] May, Bruce, 2014-08-07
[InstanceEdit:6810137] Rezsohazy, René, 2015-11-15
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5617463] May, Bruce, 2014-08-08
edited[InstanceEdit:5617425] May, Bruce, 2014-08-01
inferredFrom
input[SimpleEntity:5334804] atRA [nucleoplasm]
[EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:442488] NCOA3 [nucleoplasm] [Homo sapiens]
[Complex:209680] RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] [Homo sapiens]
[Complex:5617474] RARA,G:RXRA at HOXB1 bivalent chromatin [nucleoplasm] [Homo sapiens]
[DefinedSet:5619379] MLL3,4 complex [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:4687075] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
[LiteratureReference:4687099] A histone H3 lysine 27 demethylase regulates animal posterior development
[LiteratureReference:4687095] Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
[LiteratureReference:5617918] Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex
[LiteratureReference:5690513] Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells
modified[InstanceEdit:5617678] May, Bruce, 2014-08-13
[InstanceEdit:5618010] May, Bruce, 2014-08-16
[InstanceEdit:5619442] May, Bruce, 2014-08-22
[InstanceEdit:5620957] May, Bruce, 2014-08-28
[InstanceEdit:5690639] May, Bruce, 2015-04-30
[InstanceEdit:5693645] May, Bruce, 2015-05-17
[InstanceEdit:6808659] May, Bruce, 2015-11-08
[InstanceEdit:6810141] May, Bruce, 2015-11-15
[InstanceEdit:6810171] May, Bruce, 2015-11-15
[InstanceEdit:6810187] May, Bruce, 2015-11-16
[InstanceEdit:6810603] Matthews, Lisa, 2015-11-18
[InstanceEdit:6810604] Matthews, Lisa, 2015-11-18
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRetinoic acid activates HOXB1 chromatin
output[EntityWithAccessionedSequence:442501] NCOR1 [nucleoplasm] [Homo sapiens]
[Complex:212285] PRC2 (EZH2) Core [nucleoplasm] [Homo sapiens]
[Complex:5617470] atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] [Homo sapiens]
regulatedBy[PositiveRegulation:6810142] Positive regulation by 'HOXA1 [nucleoplasm]'
regulationReference[RegulationReference:9642943] Positive regulation by 'HOXA1 [nucleoplasm]' Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
releaseDate2015-12-15
releaseStatusNEW
reviewed[InstanceEdit:5693642] Blasi, F, 2015-05-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6812535] R-HSA-5617452.5
summation[Summation:5617931] As inferred from mouse embryos and cell lines, retinoic acid...
[Summation:6810086] As inferred from mouse embryos, HOXA1 acts synergistically w...
(hasEvent)[Pathway:5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:5617454] HOXB1 gene is transcribed [Homo sapiens]
[BlackBoxEvent:5693644] HOXB1 maintains activation of HOXB1 chromatin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775755] Update Tracker - [BlackBoxEvent:5617452] Retinoic acid activates HOXB1 chromatin - v78:[addSummation]
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No pathways have been reviewed or authored by Retinoic acid activates HOXB1 chromatin (5617452)
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