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Details on Person POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)

Class:Id	Reaction:5615637
_displayName	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)
_doRelease	TRUE
_timestamp	2025-05-01 08:43:39
authored	[InstanceEdit:5615549] Jassal, Bijay, 2014-07-25
catalystActivity	[CatalystActivity:5615563] dolichyl-phosphate-mannose-protein mannosyltransferase activity of POMT1:POMT2 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:5615549] Jassal, Bijay, 2014-07-25
crossReference	[DatabaseIdentifier:9940846] RHEA:53397
edited	[InstanceEdit:5615549] Jassal, Bijay, 2014-07-25
goBiologicalProcess	[GO_BiologicalProcess:162021] protein O-linked glycosylation via mannose
input	[SimpleEntity:449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:8931890] DAG1(30-653) [endoplasmic reticulum lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5615579] Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity [LiteratureReference:5615588] Congenital muscular dystrophies: a brief review [LiteratureReference:5615623] The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy [LiteratureReference:5615607] Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome [LiteratureReference:9940716] The expanding phenotype of POMT1 mutations: from Walker-Warburg syndrome to congenital muscular dystrophy, microcephaly, and mental retardation [LiteratureReference:9940658] An autosomal recessive limb girdle muscular dystrophy (LGMD2) with mild mental retardation is allelic to Walker-Warburg syndrome (WWS) caused by a mutation in the POMT1 gene
modified	[InstanceEdit:6785501] Jassal, Bijay, 2015-06-29 [InstanceEdit:8849757] Jassal, Bijay, 2015-12-17 [InstanceEdit:8849945] Jassal, Bijay, 2015-12-18 [InstanceEdit:8851015] Jassal, Bijay, 2016-01-05 [InstanceEdit:8931883] Jassal, Bijay, 2016-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9940703] Stephan, Ralf, 2025-03-06 [InstanceEdit:9941578] Stephan, Ralf, 2025-03-09 [InstanceEdit:9942599] Stephan, Ralf, 2025-03-18 [InstanceEdit:9944934] Stephan, Ralf, 2025-04-08 [InstanceEdit:9947108] Stephan, Ralf, 2025-05-01
name	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)
output	[SimpleEntity:449311] DOLP [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:449311] DOLP [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:449311] DOLP [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:5615647] Man-DAG1 [endoplasmic reticulum lumen] [Homo sapiens] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
precedingEvent	[Reaction:9913329] Autoproteolysis of DAG1 to alpha and beta chains [Homo sapiens] [Reaction:162715] Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane [Homo sapiens] [Reaction:162721] dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8849944] Hansen, Lars, Joshi, Hiren, 2015-12-18 [InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08 [InstanceEdit:9947107] Zaru, Rossana, 2025-05-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860897] R-HSA-5615637.4
structureModified	[InstanceEdit:9940703] Stephan, Ralf, 2025-03-06 [InstanceEdit:9941578] Stephan, Ralf, 2025-03-09
summation	[Summation:5615592] Co-expression of both protein O-mannosyl-transferases 1 and ...
(hasEvent)	[Pathway:8932504] DAG1 core M2 glycosylations [Homo sapiens] [Pathway:8932505] DAG1 core M3 glycosylations [Homo sapiens] [Pathway:8932506] DAG1 core M1 glycosylations [Homo sapiens]
(normalReaction)	[FailedReaction:5615556] Defective POMT2 does not transfer Man from Dol-P-Man to DAG1 [Homo sapiens] [FailedReaction:5615604] Defective POMT1 does not transfer Man from Dol-P-Man to DAG1 [Homo sapiens]
(precedingEvent)	[Reaction:8879117] POMGNT2 transfers GlcNAc to Man-DAG1 [Homo sapiens] [Reaction:9940735] FKTN transfers RboP to GalNAc-GlcNAc-ManP-DAG1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782766] Update Tracker - [Reaction:5615637] POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) - v58:[add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9953631] Update Tracker - [Reaction:5615637] POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) - v93:[modifyText, removeLiteratureReference, removeOutput]
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