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Details on Person SLC22A12 exchanges extracellular urate for cytosolic LACT

Class:IdReaction:561253
_displayNameSLC22A12 exchanges extracellular urate for cytosolic LACT
_doReleaseTRUE
_timestamp2025-08-13 18:09:14
authored[InstanceEdit:561229] Jassal, Bijay, 2010-03-31
catalystActivity[CatalystActivity:561239] urate transmembrane transporter activity of SLC22A12 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:561229] Jassal, Bijay, 2010-03-31
crossReference[DatabaseIdentifier:9958693] RHEA:72004
edited[InstanceEdit:561229] Jassal, Bijay, 2010-03-31
input[SimpleEntity:429056] urate [extracellular region]
[SimpleEntity:29708] LACT [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:561226] Molecular identification of a renal urate anion exchanger that regulates blood urate levels
[LiteratureReference:561250] Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia
modified[InstanceEdit:561255] Jassal, Bijay, 2010-03-31
[InstanceEdit:597617] Jassal, Bijay, 2010-04-14
[InstanceEdit:666912] Jassal, Bijay, 2010-05-04
[InstanceEdit:706450] Jassal, Bijay, 2010-05-10
[InstanceEdit:5625241] Jassal, Bijay, 2014-10-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9958692] Stephan, Ralf, 2025-06-24
[InstanceEdit:9963193] Stephan, Ralf, 2025-08-13
nameSLC22A12 exchanges extracellular urate for cytosolic LACT
URAT1 regulates urate levels in blood with exchange for organic anions
output[SimpleEntity:30034] urate [cytosol]
[SimpleEntity:373863] LACT [extracellular region]
precedingEvent
releaseDate2010-06-15
reviewed[InstanceEdit:706449] He, L, 2010-05-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104372] R-HSA-561253.3
summation[Summation:561240] Urate is a naturally occurring product of purine metabolism ...
(hasEvent)[Pathway:561048] Organic anion transport by SLC22 transporters [Homo sapiens]
(normalReaction)[FailedReaction:5625210] Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT [Homo sapiens]
(precedingEvent)[Reaction:373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol [Homo sapiens]
[Reaction:429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol [Homo sapiens]
[Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens]
[Reaction:8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol [Homo sapiens]
[Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784408] Update Tracker - [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - v54:[modifyText]
[_UpdateTracker:9785691] Update Tracker - [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - v51:[modifyText]
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