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Details on Person GLI3R binds the PTCH1 promoter

Class:Id	Reaction:5612508
_displayName	GLI3R binds the PTCH1 promoter
_doRelease	TRUE
_timestamp	2014-11-20 02:43:05
authored	[InstanceEdit:5610800] Rothfels, Karen, 2014-07-22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5612511] Rothfels, Karen, 2014-07-23
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
input	[EntityWithAccessionedSequence:5610371] GLI3R [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5612503] PTCH1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5612498] The GLI gene encodes a nuclear protein which binds specific sequences in the human genome [LiteratureReference:5358220] Gli proteins in development and disease [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis [LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612471] Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site [LiteratureReference:5612493] Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3 [LiteratureReference:5617320] GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
modified	[InstanceEdit:5617339] Rothfels, Karen, 2014-08-06 [InstanceEdit:5621806] Rothfels, Karen, 2014-09-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI3R binds the PTCH1 promoter
output	[Complex:5612507] PTCH1 gene:GLI3R [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5610752] GLI3R translocates to the nucleus [Homo sapiens] [BlackBoxEvent:5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor [Homo sapiens]
releaseDate	2014-09-30
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644643] R-HSA-5612508.2
summation	[Summation:5612502] GLI3R is a DNA-binding transcriptional repressor that recogn...
(hasEvent)	[Pathway:5610787] Hedgehog 'off' state [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5612510] Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling [Homo sapiens]
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