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Details on Person A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Class:Id	LiteratureReference:5612467
_displayName	A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
_timestamp	2014-07-23 19:43:31
author	[Person:5612465] Vokes, Steven A [Person:5612466] Ji, Hongkai [Person:5159220] Wong, Wing H [Person:3238006] McMahon, Andrew P
created	[InstanceEdit:5612468] Rothfels, Karen, 2014-07-23
journal	Genes Dev.
pages	2651-63
pubMedIdentifier	18832070
title	A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
volume	22
year	2008
(literatureReference)	[Complex:5612507] PTCH1 gene:GLI3R [nucleoplasm] [Homo sapiens] [Reaction:5612508] GLI3R binds the PTCH1 promoter [Homo sapiens] [BlackBoxEvent:5612510] Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling [Homo sapiens] [BlackBoxEvent:5635841] GLI proteins are phosphorylated [Homo sapiens] [Reaction:5635846] GLI proteins bind GLI1 gene [Homo sapiens] [Reaction:5635848] GLI proteins bind PTCH1 gene [Homo sapiens] [Reaction:5635850] GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters [Homo sapiens] [Pathway:5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription [Homo sapiens] [BlackBoxEvent:5635853] Hh-dependent expression of GLI1 gene [Homo sapiens]
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