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Details on Person NLRP3 [cytosol]

Class:Id	EntityWithAccessionedSequence:561189
_displayName	NLRP3 [cytosol]
_timestamp	2011-06-10 09:16:05
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:561190] Jupe, S, 2010-03-30
endCoordinate	1036
modified	[InstanceEdit:877366] Jupe, S, 2010-06-14
name	NLRP3 NACHT, LRR and PYD domains-containing protein 3 NALP3_HUMAN Cryopyrin
referenceEntity	[ReferenceGeneProduct:52126] UniProt:Q96P20 NLRP3 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1358535] R-HSA-561189.1
startCoordinate	1
(activeUnit)	[CatalystActivity:9712362] ATP hydrolysis activity of NLRP3:MAVS:TOMM70 [mitochondrial outer membrane]
(hasComponent)	[Complex:874086] NLRP3:SUGT1:HSP90 [cytosol] [Homo sapiens] [Complex:877226] NLRP3 elicitor small molecules:NLRP3 [cytosol] [Homo sapiens] [Complex:1250285] TXNIP:NLRP3 [cytosol] [Homo sapiens] [Complex:1306879] NLRP3 elicitor proteins:NLRP3 [cytosol] [Homo sapiens] [Complex:6783274] BRISC complex:NLRP3 [cytosol] [Homo sapiens] [Complex:9685256] NLRP3:MAVS:TOMM70 [mitochondrial outer membrane] [Homo sapiens] [Complex:9685272] 8b:NLRP3 [cytosol] [Homo sapiens] [Complex:9757077] N:NLRP3 [cytosol] [Homo sapiens] [Complex:9771252] NLRP3:oxidized mtDNA [Homo sapiens] [Complex:9792861] NLRP3:TRIM31:Ub:UBE2D1 [cytosol] [Homo sapiens] List all 12 refering instances
(input)	[Reaction:873951] SGT1:HSP90 binds inactive NLRP3 [Homo sapiens] [Reaction:1250272] TXNIP binds NLRP3 [Homo sapiens] [Reaction:9685268] SARS-CoV-1 8b binds NLRP3 [Homo sapiens] [BlackBoxEvent:9748671] CRL1 (FBXL2) polyubiquitinates NLRP3 at K689 [Homo sapiens] [BlackBoxEvent:9748776] CRL1 (BTRC) polyubiquitinates NLRP3 at K384 [Homo sapiens] [Reaction:9757097] SARS-CoV-2 N binds NLRP3 [Homo sapiens] [Reaction:9773057] PKA phosphorylates NLRP3 at S295 [Homo sapiens] [Reaction:9792854] AKT phosphorylates NLRP3 at S5 [Homo sapiens] [Reaction:9792864] MAPK8 phosphorylates NLRP3 at S198 [Homo sapiens] [Reaction:9792869] NLRP3 binds TRIM31 [Homo sapiens] List all 12 refering instances
(output)	[BlackBoxEvent:9603905] Expression of NLRP3 gene [Homo sapiens] [BlackBoxEvent:9729415] NLRP3 mRNA is translated [Homo sapiens] [Reaction:9792885] PP2A dephosphorylates NLRP3 at S5 [Homo sapiens] [Reaction:9793143] PTPN22 dephosphorylates NLRP3 at Y861 [Homo sapiens]
(repeatedUnit)	[Polymer:9685276] NLRP3 oligomer [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by NLRP3 [cytosol] (561189)