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Details on Person GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

Class:Id	BlackBoxEvent:5610758
_displayName	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
_doRelease	TRUE
_timestamp	2018-01-23 23:01:23
authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5610759] Rothfels, Karen, 2014-07-22
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
input	[Complex:5610612] ub-pS-GLI1:SUFU [ciliary base] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5609710] Dual degradation signals control Gli protein stability and tumor formation [LiteratureReference:5609824] Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination [LiteratureReference:5609813] Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
modified	[InstanceEdit:5617345] Rothfels, Karen, 2014-08-06 [InstanceEdit:5621799] Rothfels, Karen, 2014-09-05 [InstanceEdit:9035510] Rothfels, Karen, 2018-01-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
output	[EntityWithAccessionedSequence:445455] SUFU [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 [Homo sapiens] [Reaction:5610741] PKA phosphorylates GLI1 [Homo sapiens]
releaseDate	2014-09-30
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622226] R-HSA-5610758.3
summation	[Summation:5610673] In the absence of Hh signal, GLI1 is degraded by the proteas...
(hasEvent)	[Pathway:5610780] Degradation of GLI1 by the proteasome [Homo sapiens]
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No pathways have been reviewed or authored by GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (5610758)