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Details on Person GLI3 is partially degraded by the proteasome to yield the GLI3 repressor

Class:Id	BlackBoxEvent:5610754
_displayName	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
_doRelease	TRUE
_timestamp	2014-11-20 02:38:11
authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5610755] Rothfels, Karen, 2014-07-22
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
input	[Complex:5610526] 4xub-p13S-Gli3:SUFU [ciliary base] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5609753] Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb [LiteratureReference:208141] Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP [LiteratureReference:5609719] Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing [LiteratureReference:5609688] A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome [LiteratureReference:5609692] A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome
modified	[InstanceEdit:5617341] Rothfels, Karen, 2014-08-06 [InstanceEdit:5621802] Rothfels, Karen, 2014-09-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
output	[EntityWithAccessionedSequence:5610369] GLI3R [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:445455] SUFU [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5610746] SCF(beta-TrCP) ubiquitinates p-GLI3 [Homo sapiens] [Reaction:5610732] GSK3 phosphorylates p-GLI3 [Homo sapiens]
releaseDate	2014-09-30
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622425] R-HSA-5610754.2
summation	[Summation:5610646] After phosphorylation and ubiquitination, GLI3 is processed ...
(hasEvent)	[Pathway:5610785] GLI3 is processed to GLI3R by the proteasome [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5610752] GLI3R translocates to the nucleus [Homo sapiens]
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