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Details on Person KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules

Class:Id	Reaction:5610733
_displayName	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules
_doRelease	TRUE
_timestamp	2014-11-20 02:52:11
authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
compartment	[Compartment:5263228] ciliary tip
created	[InstanceEdit:5610734] Rothfels, Karen, 2014-07-22
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
input	[Polymer:5610520] microtubule [axonemal microtubule] [Homo sapiens] [EntityWithAccessionedSequence:5610395] KIF7 [ciliary tip] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5609857] The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5609768] Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components [LiteratureReference:5609737] Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function [LiteratureReference:5609854] The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling [LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation [LiteratureReference:5610134] Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling [LiteratureReference:5609787] Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling [LiteratureReference:5609864] The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development [LiteratureReference:5617323] Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo
modified	[InstanceEdit:5617366] Rothfels, Karen, 2014-08-06 [InstanceEdit:5621813] Rothfels, Karen, 2014-09-05 [InstanceEdit:5625168] D'Eustachio, Peter, 2014-10-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules
output	[Complex:5610559] KIF7:microtubule [ciliary tip] [Homo sapiens]
releaseDate	2014-09-30
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622928] R-HSA-5610733.2
summation	[Summation:5610678] KIF7, the human ortholog of Drosophila COS2, is a kinesin-4 ...
(hasEvent)	[Pathway:5610787] Hedgehog 'off' state [Homo sapiens]
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No pathways have been reviewed or authored by KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (5610733)