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Details on Person GSK3 phosphorylates p-GLI2

Class:IdReaction:5610730
_displayNameGSK3 phosphorylates p-GLI2
_doReleaseTRUE
_timestamp2014-11-20 02:31:08
authored[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity[CatalystActivity:208885] protein serine/threonine kinase activity of GSK3B [cytosol]
compartment[Compartment:5263232] ciliary base
created[InstanceEdit:5610729] Rothfels, Karen, 2014-07-22
edited[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
inferredFrom
input[Complex:5610598] p8S-GLI2:SUFU [ciliary base] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5609843] Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
modified[InstanceEdit:5617359] Rothfels, Karen, 2014-08-06
[InstanceEdit:5621809] Rothfels, Karen, 2014-09-05
[InstanceEdit:5625159] D'Eustachio, Peter, 2014-10-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGSK3 phosphorylates p-GLI2
output[Complex:5610584] p11S-GLI2:SUFU [ciliary base] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2014-09-30
reviewed[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644231] R-HSA-5610730.2
summation[Summation:5610680] Like GLI3, GLI2 has putative GSK3 sites that contribute to t...
(hasEvent)[Pathway:5610783] Degradation of GLI2 by the proteasome [Homo sapiens]
(precedingEvent)[Reaction:5610745] SCF(beta-TrCP) ubiquitinates p-GLI2 [Homo sapiens]
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No pathways have been reviewed or authored by GSK3 phosphorylates p-GLI2 (5610730)