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Details on Person OCT3 mediates renal uptake of organic cations

Class:Id	Reaction:561072
_displayName	OCT3 mediates renal uptake of organic cations
_doRelease	TRUE
_timestamp	2025-08-13 17:59:31
authored	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
catalystActivity	[CatalystActivity:549240] transmembrane transporter activity of SLC22A3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
crossReference	[DatabaseIdentifier:9958530] RHEA:73885
edited	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
input	[DefinedSet:549255] OCT3 substrates [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:549283] Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter [LiteratureReference:549238] Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney
modified	[InstanceEdit:706450] Jassal, Bijay, 2010-05-10 [InstanceEdit:706484] Jassal, Bijay, 2010-05-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958565] Stephan, Ralf, 2025-06-23 [InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
name	OCT3 mediates renal uptake of organic cations
negativePrecedingEvent	[NegativePrecedingEvent:9963180] Futile Cycle: MATEs mediate extrusion of xenobiotics [NegativePrecedingEvent:9963174] Futile Cycle: OCT1 transports organic cations out of hepatic cells [NegativePrecedingEvent:9963178] Futile Cycle: OCT2 mediates tubular secretion of organic cations in the kidney [NegativePrecedingEvent:9963181] Futile Cycle: OCT3 mediates renal clearance of organic cations
output	[DefinedSet:549326] OCT3 substrates [cytosol]
releaseDate	2010-06-15
reverseReaction	[Reaction:549304] OCT3 mediates renal clearance of organic cations [Homo sapiens] [Reaction:561072] OCT3 mediates renal uptake of organic cations [Homo sapiens]
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105179] R-HSA-561072.3
summation	[Summation:549232] The human gene SLC22A3 encodes organic cation transporter OC...
(hasEvent)	[Pathway:549127] SLC-mediated transport of organic cations [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963175] Futile Cycle: OCT3 mediates renal uptake of organic cations [NegativePrecedingEvent:9963176] Futile Cycle: OCT3 mediates renal uptake of organic cations [NegativePrecedingEvent:9963185] Futile Cycle: OCT3 mediates renal uptake of organic cations [NegativePrecedingEvent:9963191] Futile Cycle: OCT3 mediates renal uptake of organic cations
(reverseReaction)	[Reaction:549304] OCT3 mediates renal clearance of organic cations [Homo sapiens]
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