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Details on Person G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

Class:Id	LiteratureReference:5610169
_displayName	G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
_timestamp	2014-07-22 19:27:49
author	[Person:5610165] Chen, Yongbin [Person:5610171] Li, Shuang [Person:5609836] Tong, Chao [Person:5610170] Zhao, Yun [Person:5610167] Wang, Bing [Person:5610166] Liu, Yajuan [Person:5609835] Jia, Jianhang [Person:5358081] Jiang, Jin
created	[InstanceEdit:5610168] Rothfels, Karen, 2014-07-22
journal	Genes Dev.
pages	2054-67
pubMedIdentifier	20844016
title	G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
volume	24
year	2010
(literatureReference)	[BlackBoxEvent:5610763] PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal [Homo sapiens] [Reaction:5632658] Csnk1a1 binds Smo dimer [Mus musculus] [Reaction:5632661] Csnk1a1 phosphorylates Smo dimer [Mus musculus] [Reaction:5632663] Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1 [Mus musculus] [Reaction:5632665] Adrbk1 phosphorylates Smo dimer [Mus musculus] [BlackBoxEvent:5632668] SMO translocates to the cilium [Homo sapiens] [Reaction:5632670] CSNK1A1 phosphorylates SMO dimer [Homo sapiens] [Reaction:5632671] CSNK1A1 binds SMO dimer [Homo sapiens] [Reaction:5632672] ADRBK1 phosphorylates SMO dimer [Homo sapiens] [Reaction:5632674] ADRBK1 binds phosphorylated SMO dimer [Homo sapiens] List all 12 refering instances
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No pathways have been reviewed or authored by G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila (5610169)