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Details on Person Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
| Class:Id | LiteratureReference:5609813 |
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| _displayName | Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal |
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| _timestamp | 2014-07-16 20:08:19 |
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| author | [Person:5609809] Di Marcotullio, L
[Person:5609807] Greco, A
[Person:5609816] Mazzà, D
[Person:5609818] Canettieri, G
[Person:5609819] Pietrosanti, L
[Person:5609814] Infante, P
[Person:5609820] Coni, S
[Person:5609812] Moretti, M
[Person:5609808] De Smaele, E
[Person:5609815] Ferretti, E
[Person:5609817] Screpanti, I
[Person:5609810] Gulino, A |
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| created | [InstanceEdit:5609811] Rothfels, Karen, 2014-07-16 |
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| journal | Oncogene |
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| pages | 65-76 |
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| pubMedIdentifier | 20818436 |
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| title | Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal |
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| volume | 30 |
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| year | 2011 |
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| (literatureReference) | [Reaction:5610735] NUMB binds ITCH [Homo sapiens]
[Reaction:5610737] NUMB:ITCH bind and ubiquitnate GLI1 [Homo sapiens]
[BlackBoxEvent:5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP [Homo sapiens]
[BlackBoxEvent:5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH [Homo sapiens]
[Reaction:5635861] NUMB:ITCH binds GLI1 [Homo sapiens]
[Reaction:5635864] NUMB:ITCH ubiquitinates GLI1 [Homo sapiens]
[BlackBoxEvent:5635868] ub-GLI is degraded by the proteasome [Homo sapiens] |
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