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Details on Person UniProt:O15488 GYG2
Class:Id
ReferenceGeneProduct:56094
_chainChangeLog
chain:1-501 added on Fri February 6 2015
_displayName
UniProt:O15488 GYG2
_timestamp
2025-02-21 19:28:14
chain
chain:1-501
checksum
8488A09D6E564693
comment
FUNCTION Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.CATALYTIC ACTIVITY L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)CATALYTIC ACTIVITY [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)COFACTOR Glycan biosynthesis; glycogen biosynthesis.SUBUNIT Homodimer, tightly complexed to glycogen synthase.INTERACTION Localizes to glycogen granules (glycosomes) in the cytoplasm (By similarity). Cytosolic localization is dependent on the actin cytoskeleton (By similarity).ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Detected in liver (at protein level) (PubMed:9857012). Expressed preferentially in liver, heart, and pancreas (PubMed:9346895).PTM Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228.MASS SPECTROMETRY Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
