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Details on Person Toll like receptor 3 (TLR3) recognizes double-stranded RNA (...
| Class:Id | Summation:5607956 |
|---|---|
| _displayName | Toll like receptor 3 (TLR3) recognizes double-stranded RNA (... |
| _timestamp | 2015-02-15 09:00:25 |
| created | [InstanceEdit:5607968] Shamovsky, Veronica, 2014-07-14 |
| literatureReference | [LiteratureReference:5607839] Broad expression of Toll-like receptors in the human central nervous system [LiteratureReference:5602508] Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells [LiteratureReference:1678917] Herpes simplex virus encephalitis in human UNC-93B deficiency [LiteratureReference:5602643] Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis [LiteratureReference:5602442] TLR3 deficiency in patients with herpes simplex encephalitis [LiteratureReference:5607849] Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood |
| modified | [InstanceEdit:5625556] Shamovsky, Veronica, 2014-10-06 [InstanceEdit:5675065] Shamovsky, Veronica, 2015-02-15 |
| text | Toll like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate product during viral replication for most viruses. TLR3 is expressed in various tissues and cells including cells of the central nervous system (CNS) (Bsibsi M et al. 2002). TLR3 activity in neurons and glial cells was found to be critical for controlling herpes simplex virus type 1 (HSV-1) infection in CNS (Lafaille FG et al. 2012). Children with inborn errors of TLR3-mediated immunity are prone to HSV-1 encephalitis (HSE), a rare life-threatening complication during HSV-1 infection (Casrouge A et al. 2006; Perez de Diego R et al. 2010; Zhang SY et al. 2007; Herman M et al. 2012; Lafaille FG et al. 2012). The functional defect in HSE patients with TLR3 deficiency is probably due to impaired induction of type I and III interferon (IFN) by cells of the CNS, which appears to be uniquely dependent upon TLR3 for protection against HSV1 (Zhang SY et al. 2007; Guo Y et al. 2011; Lafaille FG et al. 2012). Importantly, blood cells in the periphery produce normal amounts of interferons, even in TLR3-deficient patients, which perhaps can be explained by RIGI or MDA5-mediated antiviral responses. |
| (summation) | [Pathway:5602410] TLR3 deficiency - HSE [Homo sapiens] |
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No pathways have been reviewed or authored by Toll like receptor 3 (TLR3) recognizes double-stranded RNA (... (5607956)
