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Details on Person 1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2

Class:Id	Reaction:5607754
_displayName	1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2
_doRelease	TRUE
_timestamp	2015-09-01 16:05:15
authored	[InstanceEdit:5607752] Garapati, P V, 2014-07-14
catalystActivity	[CatalystActivity:5607716] protein tyrosine kinase activity of 1,3-beta-D-glucan:p-Y15-Clec7a:Syk [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643817] protein tyrosine kinase activity of 1,3-beta-D-glucan:p-Y15-Clec7a:Syk [plasma membrane] Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5607752] Garapati, P V, 2014-07-14
edited	[InstanceEdit:5607752] Garapati, P V, 2014-07-14
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:5607628] Plcg2 [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:5607277] Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells [LiteratureReference:443435] Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
modified	[InstanceEdit:5609985] Garapati, P V, 2014-07-18 [InstanceEdit:5621626] Garapati, P V, 2014-09-02 [InstanceEdit:5621997] Garapati, P V, 2014-09-08 [InstanceEdit:5674203] Garapati, P V, 2015-02-11 [InstanceEdit:6793508] Garapati, Phani Vijay, 2015-09-01 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:5607654] p-Y753,Y759-Plcg2 [cytosol] [Mus musculus]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014-09-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5679997] R-MMU-5607754.4
summation	[Summation:5607592] Activation of SYK triggers multiple cascades, which induces ...
(inferredFrom)	[Reaction:5607745] 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG [Homo sapiens]
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No pathways have been reviewed or authored by 1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2 (5607754)