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Details on Person Accumulated NF-kB-inducing kinase (NIK) activates I kappa-B ...
| Class:Id | Summation:5607616 |
|---|---|
| _displayName | Accumulated NF-kB-inducing kinase (NIK) activates I kappa-B ... |
| _timestamp | 2014-07-18 14:32:46 |
| created | [InstanceEdit:5607612] Garapati, P V, 2014-07-14 |
| literatureReference | [LiteratureReference:5607186] Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation [LiteratureReference:1267828] NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176 |
| modified | [InstanceEdit:5609981] Garapati, P V, 2014-07-18 |
| text | Accumulated NF-kB-inducing kinase (NIK) activates I kappa-B kinase alpha (IKKA) by directly phosphorylating the Ser176 and Ser180 with in the activation loop of IKKA. This phoshorylation is required for IKKA activity (Ling et al. 1998). Besides activating IKKA, NIK also serves as a docking molecule recruiting IKKA to p100 (Xiao et al. 2004). |
| (summation) | [Reaction:5607722] Active NIK phosphorylates IKKA dimer [Homo sapiens] |
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No pathways have been reviewed or authored by Accumulated NF-kB-inducing kinase (NIK) activates I kappa-B ... (5607616)
