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Details on Person Ubiquitination of p100 is very specific. Lysine residue K855...
| Class:Id | Summation:5607600 |
|---|---|
| _displayName | Ubiquitination of p100 is very specific. Lysine residue K855... |
| _timestamp | 2015-01-14 17:05:39 |
| created | [InstanceEdit:5607612] Garapati, P V, 2014-07-14 |
| literatureReference | [LiteratureReference:5607396] Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase [LiteratureReference:5607346] Proteasomes and their kin: proteases in the machine age [LiteratureReference:5607297] NEDD8 recruits E2-ubiquitin to SCF E3 ligase [LiteratureReference:5607170] Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1) [LiteratureReference:5607320] Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha |
| modified | [InstanceEdit:5609981] Garapati, P V, 2014-07-18 [InstanceEdit:5663015] Garapati, P V, 2015-01-14 |
| text | Ubiquitination of p100 is very specific. Lysine residue K855 has been identified as the anchoring site for ubiquitin and required for signaling mediated processing of p100 to p52. In the presence of SCF-beta-TRCP E3 ligase the ubiquitin (Ub) conjugated to E2 (E2-Ub thioester) is attached to p100 at K855 (Amir et al. 2004). Several rounds of ubiquitin conjugation can produce long chains of ubiquitin moieties (polyubiquitylation), the first of which is covalently bound to p100. At this point the polyubiquitylated p100 is committed to association with, and unfolding and processing by, the 26S proteasome (Pickart & Cohen 2004). Efficient ubiquitination of phosphorylated p100 by SCF-beta-TRCP E3 ligase also requires the presence of the components of the NEDD8 pathway: UBA3 (NEDD8-activating enzyme E1 catalytic subunit), UBC12 (NEDD8-conjugating enzyme Ubc12 (E2)), NEDD8 (Neural precursor cell expressed developmentally down-regulated protein 8). NEDD8 binds and promotes a conformational change in CUL1 that may result in efficient formation of an E2-E3 complex, thus stimulating SCF complexes activity (Kawakami et al. 2001, Morimoto et al. 2000, Read et al. 2000). |
| (summation) | [BlackBoxEvent:5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [Homo sapiens] |
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