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Details on Person UniProt:Q9NY64 SLC2A8
| Class:Id | ReferenceGeneProduct:56076 |
|---|---|
| _chainChangeLog | chain:1-477 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NY64 SLC2A8 |
| _timestamp | 2024-11-03 19:54:00 |
| chain | chain:1-477 |
| checksum | 0B480F94AF063316 |
| comment | FUNCTION Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate.CATALYTIC ACTIVITY D-glucose(out) = D-glucose(in)CATALYTIC ACTIVITY D-fructose(out) = D-fructose(in)CATALYTIC ACTIVITY L-dehydroascorbate(out) = L-dehydroascorbate(in)CATALYTIC ACTIVITY alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)ACTIVITY REGULATION Inhibited by cytochalasin B.SUBUNIT Interacts with AP2B1.SUBCELLULAR LOCATION Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration.TISSUE SPECIFICITY Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.INDUCTION In testis, down-regulated by estrogen.SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. |
| description | recommendedName: fullName evidence="9"Solute carrier family 2, facilitated glucose transporter member 8 alternativeName: fullName evidence="8"Glucose transporter type 8 shortName evidence="8"GLUT-8 alternativeName: fullName evidence="7"Glucose transporter type X1 |
| geneName | SLC2A8 GLUT8 GLUTX1 |
| identifier | Q9NY64 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Cytoplasmic vesicle Glycoprotein Membrane Proteomics identification Reference proteome Sugar transport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SLC2A8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994846] ENSEMBL:ENSG00000136856 SLC2A8 [Homo sapiens] |
| secondaryIdentifier | SL2A8_HUMAN Q8WUZ9 Q9NSC4 |
| sequenceLength | 477 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:429140] SLC2A8 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8869111] SLC2A8 [clathrin-coated endocytic vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NY64 SLC2A8 (56076)
