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Details on Person Activation of SYK triggers multiple cascades, which induces ...
| Class:Id | Summation:5607592 |
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| _displayName | Activation of SYK triggers multiple cascades, which induces ... |
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| _timestamp | 2014-07-18 18:45:41 |
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| created | [InstanceEdit:5607612] Garapati, P V, 2014-07-14 |
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| literatureReference | [LiteratureReference:5607277] Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells
[LiteratureReference:5607135] Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization
[LiteratureReference:5607371] Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
[LiteratureReference:443435] Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites |
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| modified | [InstanceEdit:5609981] Garapati, P V, 2014-07-18
[InstanceEdit:5609985] Garapati, P V, 2014-07-18 |
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| text | Activation of SYK triggers multiple cascades, which induces NF-kB activation through a CARD9-dependent pathway. Phospholipase C-gamma 2 (PLCG2) is one of the key signaling components of the CLEC7A (Dectin-1) pathway that connects SYK activation to CARD9 recruitment. PLCG2 is activated upon CLEC7A engagement and triggers an intracellular Ca2+ flux. SYK and Src family kinases are upstream of PLCG2 (Xu et al. 2009, Tassi et al. 2009, Gorjestani et al. 2011). SYK phosphorylates PLCG2 on Y753 and Y759, enhancing the activity of PLCG2 (Suzuki-Inoue et al. 2004). |
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| (summation) | [Reaction:5607745] 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG [Homo sapiens]
[Reaction:5607754] 1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2 [Mus musculus] |
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