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Details on Person Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase

Class:Id	LiteratureReference:5607396
_displayName	Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase
_timestamp	2014-07-11 09:51:57
author	[Person:5607399] Amir, Ruthie E [Person:5607194] Haecker, Hans [Person:1273426] Karin, M [Person:5607300] Ciechanover, Aaron
created	[InstanceEdit:5607215] Garapati, P V, 2014-07-11
journal	Oncogene
pages	2540-7
pubMedIdentifier	14676825
title	Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase
volume	23
year	2004
(literatureReference)	[CatalystActivityReference:9644057] ubiquitin-protein transferase activity of Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase [Summation:5607586] Once polyubiquitinated, the precursor p100 undergoes 26S pro... [Summation:5607600] Ubiquitination of p100 is very specific. Lysine residue K855... [BlackBoxEvent:5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [Homo sapiens] [BlackBoxEvent:5607731] 26S proteasome processes p-7S-p100:RELB to form p52:RELB [Homo sapiens]
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