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Details on Person A soluble form of PROCR (sEPCR) fully retains the ability to...

Class:IdSummation:5607018
_displayNameA soluble form of PROCR (sEPCR) fully retains the ability to...
_timestamp2014-07-21 14:44:31
created[InstanceEdit:5607040] Jupe, Steve, 2014-07-09
literatureReference[LiteratureReference:5607049] Identification of functional endothelial protein C receptor in human plasma
[LiteratureReference:5607034] Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes
[LiteratureReference:5607032] Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
[LiteratureReference:5607027] The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18
[LiteratureReference:5607047] Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function
[LiteratureReference:5610090] Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function
modified[InstanceEdit:5610111] Jupe, Steve, 2014-07-21
textA soluble form of PROCR (sEPCR) fully retains the ability to bind Protein C and Activated protein C (Kurosawa et al. 1997). This form increases up to 5-fold in patients with sepsis or systemic lupus erythematosus (Kurosawa et al. 1998), either from vascular injury or through a regulated proteolytic release of soluble receptor (Gu et al. 2000). sEPCR inhibits protein C activation over large vessel endothelium in culture, reflecting competition between the soluble and cell surface forms of PROCR (Liaw et al. 2000).
(summation)[Reaction:5606996] Soluble PROCR binds activated protein C [Homo sapiens]
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