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Details on Person Activated protein C cleaves factor VIIIa

Class:Id	Reaction:5607002
_displayName	Activated protein C cleaves factor VIIIa
_doRelease	TRUE
_timestamp	2014-11-20 02:35:38
authored	[InstanceEdit:5607780] Jupe, Steve, 2014-07-14
catalystActivity	[CatalystActivity:141025] serine-type endopeptidase activity of Activated protein C:Protein S [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5607040] Jupe, Steve, 2014-07-09
edited	[InstanceEdit:5627264] Jupe, Steve, 2014-07-28
input	[Complex:158307] factor VIIIa [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5591058] Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562
modified	[InstanceEdit:5627263] Jupe, Steve, 2014-10-17 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5633086] Jassal, Bijay, 2014-10-30 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated protein C cleaves factor VIIIa
output	[Complex:5607059] Inactivated factor VIII [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5606999] F8(356-372) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5607008] F8(582-640) [extracellular region] [Homo sapiens]
regulatedBy	[PositiveRegulation:5607102] Positive regulation by 'factor V [extracellular region]'
releaseDate	2014-12-11
reviewed	[InstanceEdit:5627265] Mumford, Andrew, 2014-09-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622368] R-HSA-5607002.3
summation	[Summation:5607041] Activated Protein C (APC) is best known for its anticoagulan...
systematicName	Activated protein C:Protein S cleaves factor VIIIa to form Inactivated factor VIII, F8(356-372) and F8(582-640)
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769739] Regulation of clotting cascade [Homo sapiens]
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No pathways have been reviewed or authored by Activated protein C cleaves factor VIIIa (5607002)