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Details on Person MeR-Piwil4:2'-O-methyl-piRNA:Tdrd9:Mael:Tdrkh dissociates and MeR-Piwil4:2'-O-methyl-piRNA, Tdrd9, Mael translocate from cytosol to nucleus in unknown association and unknown order of events

Class:Id	BlackBoxEvent:5606256
_displayName	MeR-Piwil4:2'-O-methyl-piRNA:Tdrd9:Mael:Tdrkh dissociates and MeR-Piwil4:2'-O-methyl-piRNA, Tdrd9, Mael translocate from cytosol to nucleus in unknown association and unknown order of events
_doRelease	TRUE
_timestamp	2014-11-20 02:39:14
authored	[InstanceEdit:5605404] May, Bruce, 2014-07-05
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:5606230] May, Bruce, 2014-07-07
edited	[InstanceEdit:5605404] May, Bruce, 2014-07-05
input	[Complex:5606238] MeR-Piwil4:2'-O-methyl-piRNA:Tdrd9:Mael:Tdrkh [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:5606248] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes [LiteratureReference:5606236] MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline [LiteratureReference:5606223] Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile [LiteratureReference:5606208] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline [LiteratureReference:5605232] Cytoplasmic compartmentalization of the fetal piRNA pathway in mice [LiteratureReference:5608261] Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline
modified	[InstanceEdit:5606950] May, Bruce, 2014-07-07 [InstanceEdit:5607985] May, Bruce, 2014-07-14 [InstanceEdit:5626893] May, Bruce, 2014-10-13 [InstanceEdit:5627396] May, Bruce, 2014-10-18 [InstanceEdit:5629248] May, Bruce, 2014-10-25 [InstanceEdit:5629253] May, Bruce, 2014-10-25 [InstanceEdit:5633488] May, Bruce, 2014-11-01 [InstanceEdit:5634125] Jassal, Bijay, 2014-11-03 [InstanceEdit:5635951] May, Bruce, 2014-11-08 [InstanceEdit:5636010] May, Bruce, 2014-11-08 [InstanceEdit:5636064] May, Bruce, 2014-11-09 [InstanceEdit:5637447] May, Bruce, 2014-11-10 [InstanceEdit:5637448] May, Bruce, 2014-11-10 [InstanceEdit:5637449] May, Bruce, 2014-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MeR-Piwil4:2'-O-methyl-piRNA:Tdrd9:Mael:Tdrkh dissociates and MeR-Piwil4:2'-O-methyl-piRNA, Tdrd9, Mael translocate from cytosol to nucleus in unknown association and unknown order of events Transport of Piwil4:piRNA to the nucleus
output	[EntityWithAccessionedSequence:5605357] Tdrd9 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5608259] Tdrkh [cytosol] [Mus musculus] [EntityWithAccessionedSequence:5636061] Mael [nucleoplasm] [Mus musculus] [Complex:5606262] MeR-Piwil4:2'-O-methyl-piRNA [nucleoplasm] [Mus musculus]
precedingEvent	[Reaction:5629230] Henmt1 methylates 2' hydroxyl at 3' end of piRNA in MeR-Piwil4:piRNA:Tdrd9:Mael:Tdrkh [Mus musculus] [BlackBoxEvent:5606210] Unknown nuclease cleaves cleaved transposon RNA in MeR-Piwil4:cleaved transposon RNA:Tdrd9:Mael:Tdrkh [Mus musculus]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5629251] Saito, Kuniaki, 2014-10-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5622393] R-MMU-5606256.2
summation	[Summation:5606947] Piwil4 is loaded with piRNA in the cytosol and then transloc...
(inferredFrom)	[BlackBoxEvent:5601897] MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events [Homo sapiens]
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No pathways have been reviewed or authored by MeR-Piwil4:2'-O-methyl-piRNA:Tdrd9:Mael:Tdrkh dissociates and MeR-Piwil4:2'-O-methyl-piRNA, Tdrd9, Mael translocate from cytosol to nucleus in unknown association and unknown order of events (5606256)