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Details on Person Pld6 dimer cleaves primary piRNA transcript to pre-piRNA

Class:Id	Reaction:5605262
_displayName	Pld6 dimer cleaves primary piRNA transcript to pre-piRNA
_doRelease	TRUE
_timestamp	2017-04-07 06:43:15
authored	[InstanceEdit:5603160] May, Bruce, 2014-06-29
catalystActivity	[CatalystActivity:5605244] RNA endonuclease activity of Pld6 dimer [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9643606] endoribonuclease activity of Pld6 dimer [mitochondrial outer membrane] Structure and function of Zucchini endoribonuclease in piRNA biogenesis
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:5605294] May, Bruce, 2014-07-05
edited	[InstanceEdit:5603160] May, Bruce, 2014-06-29
input	[GenomeEncodedEntity:5605242] primary piRNA transcript [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:5605253] Structure and function of Zucchini endoribonuclease in piRNA biogenesis [LiteratureReference:5605312] The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis [LiteratureReference:5605394] MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline [LiteratureReference:5629236] A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis
modified	[InstanceEdit:5606266] May, Bruce, 2014-07-07 [InstanceEdit:5606991] May, Bruce, 2014-07-08 [InstanceEdit:5615694] May, Bruce, 2014-07-29 [InstanceEdit:5626893] May, Bruce, 2014-10-13 [InstanceEdit:5627396] May, Bruce, 2014-10-18 [InstanceEdit:5629248] May, Bruce, 2014-10-25 [InstanceEdit:5629253] May, Bruce, 2014-10-25 [InstanceEdit:5632360] Jassal, Bijay, 2014-10-28 [InstanceEdit:5632370] Jassal, Bijay, 2014-10-28 [InstanceEdit:5635951] May, Bruce, 2014-11-08 [InstanceEdit:8984469] May, Bruce, 2017-04-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Pld6 dimer cleaves primary piRNA transcript to pre-piRNA
output	[GenomeEncodedEntity:5605348] pre-piRNA [cytosol] [Mus musculus]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5629251] Saito, Kuniaki, 2014-10-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5622725] R-MMU-5605262.4
summation	[Summation:5606242] Mouse PLD6 (MitoPLD) located on the cytoplasmic face of the ...
(inferredFrom)	[Reaction:5601887] PLD6 dimer cleaves primary piRNA transcript to pre-piRNA [Homo sapiens]
(precedingEvent)	[Reaction:5605279] Complexed Piwil2 binds pre-piRNA [Mus musculus] [BlackBoxEvent:5605344] Unknown nuclease cleaves pre-piRNA in 4xMeR-Piwil1:pre-piRNA:Tdrd6:Tdrkh [Mus musculus] [Reaction:5615685] Complexed Piwil1 binds pre-piRNA [Mus musculus]
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No pathways have been reviewed or authored by Pld6 dimer cleaves primary piRNA transcript to pre-piRNA (5605262)