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Details on Person Expression of CEBPA

Class:Id	BlackBoxEvent:560491
_displayName	Expression of CEBPA
_doRelease	TRUE
_timestamp	2014-11-16 08:23:08
authored	[InstanceEdit:556811] May, B, 2010-03-23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:560489] May, B, 2010-03-24
edited	[InstanceEdit:556811] May, B, 2010-03-23
inferredFrom	[BlackBoxEvent:442497] Expression of Cebpa [Mus musculus]
input	[EntityWithAccessionedSequence:5640210] CEBPA gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:560478] Identification of novel PPARgamma target genes in primary human adipocytes
modified	[InstanceEdit:766126] May, B, 2010-05-21 [InstanceEdit:847703] May, B, 2010-05-30 [InstanceEdit:977273] May, B, 2010-10-18 [InstanceEdit:1008273] May, B, 2010-11-11 [InstanceEdit:1082224] May, B, 2010-11-29 [InstanceEdit:1183014] May, B, 2011-02-09 [InstanceEdit:2026094] May, B, 2011-12-22 [InstanceEdit:5640212] May, Bruce, 2014-11-16 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of CEBPA
output	[EntityWithAccessionedSequence:381289] CEBPA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands [Homo sapiens] [Reaction:381290] PPARG:RXRA heterodimer binds to PPARG corepressors [Homo sapiens] [BlackBoxEvent:2026091] FABP4 transports lipids Into the nucleus [Homo sapiens] [BlackBoxEvent:977271] Expression of EBF1 [Homo sapiens] [BlackBoxEvent:381337] Expression of CEBPB in adipogenesis [Homo sapiens] [BlackBoxEvent:977392] Expression of CEBPD [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:390510] Positive gene expression regulation by 'EBF1 [nucleoplasm]' [PositiveGeneExpressionRegulation:560533] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' [NegativeGeneExpressionRegulation:976198] Negative gene expression regulation by 'WNT1,WNT10B [extracellular region]' [NegativeGeneExpressionRegulation:976204] Negative gene expression regulation by 'TNF(77-233) [extracellular region]' [NegativeGeneExpressionRegulation:976237] Negative gene expression regulation by 'TGFB1 [extracellular region]'
regulationReference	[RegulationReference:9641879] Negative gene expression regulation by 'TNF(77-233) [extracellular region]' TNF-alpha inhibits 3T3-L1 adipocyte differentiation without downregulating the expression of C/EBPbeta and delta [RegulationReference:9642082] Negative gene expression regulation by 'WNT1,WNT10B [extracellular region]' Inhibition of adipogenesis by Wnt signaling [RegulationReference:9642177] Positive gene expression regulation by 'EBF1 [nucleoplasm]' Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade [RegulationReference:9642395] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' Identification of novel PPARgamma target genes in primary human adipocytes [RegulationReference:9642496] Negative gene expression regulation by 'TGFB1 [extracellular region]' Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by antagonists of adipogenesis
releaseDate	2011-03-15
reviewed	[InstanceEdit:422150] D'Eustachio, P, 2009-05-26 22:09:50 [InstanceEdit:1183001] Sethi, JK, 2011-02-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1225005] R-HSA-560491.5
summation	[Summation:560502] The CEBPA gene is transcribed to yield mRNA and the mRNA is ... [Summation:976196] As inferred from mouse, TNF-alpha inhibits expression of CEB... [Summation:976189] As inferred from mouse 3T3-L1 cells, Wnt-1 and Wnt-10b inhib... [Summation:560530] The PPARG:RXRA heterodimer bound to fatty acids activates tr... [Summation:560503] The activation of expression of CEBPA by EBF1 is inferred fr... [Summation:976187] As inferred from mouse, TGF-beta inhibits expression of CEPB...
(hasEvent)	[Pathway:381340] Transcriptional regulation of white adipocyte differentiation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1183003] Expression of Leptin [Homo sapiens] [BlackBoxEvent:1183032] Expression of GLUT4 [Homo sapiens] [BlackBoxEvent:1183058] Expression of Adiponectin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775501] Update Tracker - [BlackBoxEvent:560491] Expression of CEBPA - v78:[addSummation] [_UpdateTracker:9785696] Update Tracker - [BlackBoxEvent:560491] Expression of CEBPA - v51:[addInput]
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No pathways have been reviewed or authored by Expression of CEBPA (560491)