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Details on Person Expression of ANGPTL4

Class:Id	BlackBoxEvent:560473
_displayName	Expression of ANGPTL4
_doRelease	TRUE
_timestamp	2025-07-21 16:37:29
authored	[InstanceEdit:556811] May, B, 2010-03-23
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:560489] May, B, 2010-03-24
edited	[InstanceEdit:556811] May, B, 2010-03-23
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[EntityWithAccessionedSequence:5640194] ANGPTL4 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:560492] Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis [LiteratureReference:561153] Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
modified	[InstanceEdit:766126] May, B, 2010-05-21 [InstanceEdit:847703] May, B, 2010-05-30 [InstanceEdit:1008273] May, B, 2010-11-11 [InstanceEdit:1082224] May, B, 2010-11-29 [InstanceEdit:1183014] May, B, 2011-02-09 [InstanceEdit:1989744] May, B, 2011-11-13 [InstanceEdit:5640212] May, Bruce, 2014-11-16 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626988] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9960253] D'Eustachio, Peter, 2025-07-08 [InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21
name	Expression of ANGPTL4 Induction of Angiopoietin-related protein 4 (ANGPTL4) Expression
output	[EntityWithAccessionedSequence:381271] ANGPTL4 [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands [Homo sapiens] [Reaction:381290] PPARG:RXRA heterodimer binds to PPARG corepressors [Homo sapiens] [BlackBoxEvent:2026091] FABP4 transports lipids Into the nucleus [Homo sapiens] [BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] [BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA [Homo sapiens] [Reaction:2026996] FABP1 transports fatty acids into the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:560539] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' [PositiveGeneExpressionRegulation:1989823] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]'
regulationReference	[RegulationReference:9641197] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis [RegulationReference:9642337] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
releaseDate	2011-03-15
reviewed	[InstanceEdit:422150] D'Eustachio, P, 2009-05-26 22:09:50 [InstanceEdit:1183001] Sethi, JK, 2011-02-09 [InstanceEdit:425906] Kersten, S, 2009-06-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1224934] R-HSA-560473.7
summation	[Summation:560516] The ANGPTL4 gene is transcribed to yield mRNA and the mRNA i... [Summation:560524] The PPARG:RXRA heterodimer bound to fatty acids activates tr...
(hasEvent)	[Pathway:381340] Transcriptional regulation of white adipocyte differentiation [Homo sapiens] [Pathway:1989781] PPARA activates gene expression [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775700] Update Tracker - [BlackBoxEvent:560473] Expression of ANGPTL4 - v78:[addSummation] [_UpdateTracker:9785664] Update Tracker - [BlackBoxEvent:560473] Expression of ANGPTL4 - v51:[addInput] [_UpdateTracker:9789000] Update Tracker - [BlackBoxEvent:560473] Expression of ANGPTL4 - v39:[addLiteratureReference, addRegulator]
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No pathways have been reviewed or authored by Expression of ANGPTL4 (560473)