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Details on Person TPMT does not transfer CH3 from AdoMet to 6MP

Class:IdFailedReaction:5603379
_displayNameTPMT does not transfer CH3 from AdoMet to 6MP
_doReleaseTRUE
_timestamp2014-11-20 02:30:32
authored[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01
catalystActivity[CatalystActivity:9631841] thiopurine S-methyltransferase activity of TPMT mutants [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01
disease[Disease:5602847] inherited metabolic disorder
edited[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01
entityFunctionalStatus[EntityFunctionalStatus:5603347] loss_of_function of TPMT mutants [cytosol]
input[SimpleEntity:158619] 6MP [cytosol]
[SimpleEntity:71284] AdoMet [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5603364] Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism
[LiteratureReference:5603340] Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23
[LiteratureReference:5603350] Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
modified[InstanceEdit:5603382] Jassal, Bijay, 2014-07-01
[InstanceEdit:5603394] Jassal, Bijay, 2014-07-01
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5633254] Matthews, Lisa, 2014-10-31
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635755] Matthews, Lisa, 2014-11-07
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTPMT does not transfer CH3 from AdoMet to 6MP
normalReaction
releaseDate2014-12-11
reviewed[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644208] R-HSA-5603379.3
summation[Summation:5603355] 6-mercaptopurine (6MP) is used in the treatment of inflammat...
systematicNameTPMT mutants do not transfer CH3 from AdoMet to 6MP
(hasEvent)[Pathway:5578995] Defective TPMT causes TPMT deficiency [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778253] Update Tracker - [FailedReaction:5603379] TPMT does not transfer CH3 from AdoMet to 6MP - v68:[addCatalystActivity]
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