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Details on Person Defective OPLAH does not hydrolyse OPRO

Class:IdFailedReaction:5603208
_displayNameDefective OPLAH does not hydrolyse OPRO
_doReleaseTRUE
_timestamp2015-06-02 02:07:36
authored[InstanceEdit:5603195] Jassal, Bijay, 2014-06-30
catalystActivity[CatalystActivity:9631719] 5-oxoprolinase (ATP-hydrolyzing) activity of OPLAH mutants [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5603195] Jassal, Bijay, 2014-06-30
disease[Disease:5602847] inherited metabolic disorder
edited[InstanceEdit:5603195] Jassal, Bijay, 2014-06-30
entityFunctionalStatus[EntityFunctionalStatus:5603197] loss_of_function of OPLAH mutants [cytosol]
input[SimpleEntity:1247942] OPRO [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5603196] 5-Oxoprolinase deficiency: report of the first human OPLAH mutation
[LiteratureReference:5603182] 5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH) Missense Changes
modified[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5633253] Matthews, Lisa, 2014-10-31
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635755] Matthews, Lisa, 2014-11-07
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective OPLAH does not hydrolyse OPRO
normalReaction
releaseDate2014-12-11
reviewed[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6781758] R-HSA-5603208.3
summation[Summation:5603235] The gamma-glutamyl cycle is a six-enzyme cycle that represen...
systematicNameOPLAH mutants do not hydrolyse OPRO
(hasEvent)[Pathway:5578998] Defective OPLAH causes OPLAHD [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778039] Update Tracker - [FailedReaction:5603208] Defective OPLAH does not hydrolyse OPRO - v68:[addCatalystActivity]
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