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Details on Person Defective MAT1A does not transfer Ado from ATP to L-Met

Class:Id	FailedReaction:5603087
_displayName	Defective MAT1A does not transfer Ado from ATP to L-Met
_doRelease	TRUE
_timestamp	2019-02-25 17:10:57
authored	[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
catalystActivity	[CatalystActivity:9638105] methionine adenosyltransferase activity of MAT1A mutant multimers [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
disease	[Disease:5579115] hypermethioninemia
edited	[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
entityFunctionalStatus	[EntityFunctionalStatus:5603113] loss_of_function of MAT1A mutant multimers [cytosol]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:174390] L-Met [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5603116] Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency [LiteratureReference:5603110] Normal brain myelination in a patient homozygous for a mutation that encodes a severely truncated methionine adenosyltransferase I/III
modified	[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01 [InstanceEdit:5623544] Jassal, Bijay, 2014-09-15 [InstanceEdit:5627273] Jassal, Bijay, 2014-10-17 [InstanceEdit:5633253] Matthews, Lisa, 2014-10-31 [InstanceEdit:5634120] Jassal, Bijay, 2014-11-03 [InstanceEdit:5635755] Matthews, Lisa, 2014-11-07 [InstanceEdit:9638107] Jassal, Bijay, 2019-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective MAT1A does not transfer Ado from ATP to L-Met
normalReaction	[Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622286] R-HSA-5603087.3
summation	[Summation:5603075] S-adenosylmethionine (AdoMet, SAM) is an important methyl do...
systematicName	MAT1A mutants do not transfer Ado from ATP to L-Met
(hasEvent)	[Pathway:5579024] Defective MAT1A causes MATD [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778623] Update Tracker - [FailedReaction:5603087] Defective MAT1A does not transfer Ado from ATP to L-Met - v68:[addCatalystActivity]
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