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Details on Person Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG
| Class:Id | FailedReaction:5602984 |
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| _displayName | Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG |
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| _doRelease | TRUE |
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| _timestamp | 2018-01-25 16:42:50 |
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| authored | [InstanceEdit:5602968] Jassal, Bijay, 2014-06-25 |
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| catalystActivity | [CatalystActivity:9631962] glutathione gamma-glutamate hydrolase activity of GGT1 mutants [plasma membrane] |
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| compartment | [Compartment:876] plasma membrane
[Compartment:984] extracellular region |
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| created | [InstanceEdit:5602968] Jassal, Bijay, 2014-06-25 |
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| disease | [Disease:5602847] inherited metabolic disorder |
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| edited | [InstanceEdit:5602968] Jassal, Bijay, 2014-06-25 |
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| entityFunctionalStatus | [EntityFunctionalStatus:5603013] loss_of_function of GGT1 mutants [plasma membrane] |
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| input | [DefinedSet:5490253] AFXBO-SG,AFNBO-SG [extracellular region]
[SimpleEntity:109276] H2O [extracellular region] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:5602886] Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis
[LiteratureReference:5602861] Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase
[LiteratureReference:5602995] Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit |
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| modified | [InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5633253] Matthews, Lisa, 2014-10-31
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635755] Matthews, Lisa, 2014-11-07
[InstanceEdit:8981151] Jassal, Bijay, 2017-03-02
[InstanceEdit:9035965] Jassal, Bijay, 2018-01-25
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG |
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| normalReaction |
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| releaseDate | 2014-12-11 |
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| reviewed | [InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:6781757] R-HSA-5602984.5 |
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| summation | [Summation:5602844] To be excreted in urine, glutathione conjugates undergo seve... |
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| systematicName | GGT1 mutants do not hydrolyse AFXBO-SG,AFNBO-SG, GSH |
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| (hasEvent) | [Pathway:9035968] Defective GGT1 in aflatoxin detoxification causes GLUTH [Homo sapiens] |
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| (updatedInstance) | [_UpdateTracker:9778600] Update Tracker - [FailedReaction:5602984] Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG - v68:[addCatalystActivity]
[_UpdateTracker:9779881] Update Tracker - [FailedReaction:5602984] Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG - v64:[add_removeInput, modifyText] |
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