Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Defective GCLC does not ligate L-Glu to L-Cys

Class:IdFailedReaction:5602892
_displayNameDefective GCLC does not ligate L-Glu to L-Cys
_doReleaseTRUE
_timestamp2015-06-02 02:07:34
authored[InstanceEdit:5602968] Jassal, Bijay, 2014-06-25
catalystActivity[CatalystActivity:9631843] glutamate-cysteine ligase activity of GCLC mutants:GCLM [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5602968] Jassal, Bijay, 2014-06-25
disease[Disease:5602914] hemolytic anemia
edited[InstanceEdit:5602968] Jassal, Bijay, 2014-06-25
entityFunctionalStatus[EntityFunctionalStatus:5602956] loss_of_function of GCLC mutants:GCLM [cytosol]
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:111707] L-Cys [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5602919] The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency
[LiteratureReference:5602996] A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia
[LiteratureReference:5602991] A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production
modified[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
[InstanceEdit:5622022] Jassal, Bijay, 2014-09-08
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5633253] Matthews, Lisa, 2014-10-31
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635755] Matthews, Lisa, 2014-11-07
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective GCLC does not ligate L-Glu to L-Cys
normalReaction
releaseDate2014-12-11
reviewed[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6781755] R-HSA-5602892.3
summation[Summation:5602911] Gamma-glutamylcysteine ligase (GCL) catalyses the first and ...
systematicNameGCLC mutants do not ligate L-Glu to L-Cys
(hasEvent)[Pathway:5578999] Defective GCLC causes HAGGSD [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778464] Update Tracker - [FailedReaction:5602892] Defective GCLC does not ligate L-Glu to L-Cys - v68:[addCatalystActivity]
[Change default viewing format]
No pathways have been reviewed or authored by Defective GCLC does not ligate L-Glu to L-Cys (5602892)
Follow Reactome