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Details on Person Defective IRAK4 does not form complex with MyD88 within TLR7/8 complex

Class:Id	FailedReaction:5602684
_displayName	Defective IRAK4 does not form complex with MyD88 within TLR7/8 complex
_doRelease	FALSE
_timestamp	2016-07-15 23:49:57
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5602721] Shamovsky, Veronica, 2014-06-24
disease	[Disease:5228860] primary immunodeficiency disease
entityFunctionalStatus	[EntityFunctionalStatus:5602633] loss_of_function of IRAK4 R12C [cytosol]
input	[EntityWithAccessionedSequence:5602511] IRAK4 R12C [cytosol] [Homo sapiens] [Complex:450120] IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5602589] Functional assessment of the mutational effects of human IRAK4 and MyD88 genes [LiteratureReference:2445189] TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15
name	Defective IRAK4 does not form complex with MyD88 within TLR7/8 complex
normalReaction	[Reaction:446648] IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8907998] R-HSA-5602684.1
(hasEvent)	[Pathway:5603040] IRAK4 deficiency (TLR7/8/9) [Homo sapiens]
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