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Details on Person Defective MyD88 does not bind MAL(TIRAP):TLR2/4

Class:Id	FailedReaction:5602606
_displayName	Defective MyD88 does not bind MAL(TIRAP):TLR2/4
_doRelease	TRUE
_timestamp	2019-02-25 16:13:37
authored	[InstanceEdit:5545427] Shamovsky, V, 2014-05-21
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5602721] Shamovsky, Veronica, 2014-06-24
disease	[Disease:5228860] primary immunodeficiency disease
edited	[InstanceEdit:5673719] Shamovsky, Veronica, 2015-02-09
entityFunctionalStatus	[EntityFunctionalStatus:5602493] loss_of_function of MyD88 R196C [cytosol]
input	[EntityWithAccessionedSequence:5602329] MyD88 R196C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5602329] MyD88 R196C [cytosol] [Homo sapiens] [Complex:2201325] activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5602589] Functional assessment of the mutational effects of human IRAK4 and MyD88 genes [LiteratureReference:5602580] Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
modified	[InstanceEdit:5607983] Shamovsky, Veronica, 2014-07-14 [InstanceEdit:5627001] Shamovsky, Veronica, 2014-10-14 [InstanceEdit:5627584] Shamovsky, Veronica, 2014-10-20 [InstanceEdit:5633253] Matthews, Lisa, 2014-10-31 [InstanceEdit:5635723] Shamovsky, Veronica, 2014-11-07 [InstanceEdit:5638364] Shamovsky, Veronica, 2014-11-14 [InstanceEdit:5643753] Shamovsky, Veronica, 2014-11-17 [InstanceEdit:5675061] Shamovsky, Veronica, 2015-02-15 [InstanceEdit:5675793] Shamovsky, Veronica, 2015-02-16 [InstanceEdit:9628612] Shamovsky, Veronica, 2018-11-09 [InstanceEdit:9638084] Shamovsky, Veronica, 2019-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective MyD88 does not bind MAL(TIRAP):TLR2/4
normalReaction	[Reaction:166072] MyD88 forms a complex with TIRAP:activated TLR2/4 [Homo sapiens]
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:180800] Neisseria meningitidis serogroup B
releaseDate	2015-03-19
reviewed	[InstanceEdit:5621924] D'Eustachio, Peter, 2014-09-06 [InstanceEdit:5675062] McDonald, Douglas R, 2015-02-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679750] R-HSA-5602606.4
summation	[Summation:5607954] The sorting MyD88 adaprtor-like (MAL or TIRAP) normally recr...
systematicName	Defective MyD88 does not bind MAL:PI(4,5)P2:BTK:activated TLR2/4
(hasEvent)	[Pathway:5602498] MyD88 deficiency (TLR2/4) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778257] Update Tracker - [FailedReaction:5602606] Defective MyD88 does not bind MAL(TIRAP):TLR2/4 - v68:[add_removeInput]
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