Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Janus kinase 3 (JAK3) binds to interleukin (IL)-2 receptor g...
| Class:Id | Summation:5602409 |
|---|---|
| _displayName | Janus kinase 3 (JAK3) binds to interleukin (IL)-2 receptor g... |
| _timestamp | 2014-06-24 07:08:44 |
| created | [InstanceEdit:5602721] Shamovsky, Veronica, 2014-06-24 |
| literatureReference | [LiteratureReference:539073] Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain [LiteratureReference:1213488] The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals |
| text | Janus kinase 3 (JAK3) binds to interleukin (IL)-2 receptor gamma chain (IL2RG) via its N-terminal JH6 and JH7-domains (Chen et al. 1997; Cacalano et al. 1999). Mutations found in JH6 or JH7 domains are thought to affect JAK3 binding to IL2RG . Here we describe a loss of function of JAK3 protein caused by several missense variants and one inframe deletion in the region of JH6 and JH7. |
| (summation) | [FailedReaction:5602695] Defective JAK3 does not bind IL2RG [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Janus kinase 3 (JAK3) binds to interleukin (IL)-2 receptor g... (5602409)
