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Details on Person Defective CYP4F22 does not 20-hydroxylate TrXA3
| Class:Id | FailedReaction:5602272 |
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| _displayName | Defective CYP4F22 does not 20-hydroxylate TrXA3 |
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| _doRelease | TRUE |
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| _timestamp | 2016-09-23 19:32:26 |
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| authored | [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 |
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| catalystActivity | [CatalystActivity:9631948] monooxygenase activity of CYP4F22 mutants [endoplasmic reticulum membrane] |
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| compartment | [Compartment:70101] cytosol |
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| created | [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 |
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| disease | [Disease:5602266] autosomal recessive congenital ichthyosis |
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| edited | [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 |
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| entityFunctionalStatus | [EntityFunctionalStatus:5602273] loss_of_function of CYP4F22 mutants [endoplasmic reticulum membrane] |
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| input | [SimpleEntity:2142713] TrXA3 [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:216607] Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3
[LiteratureReference:5602270] Rapid detection of homozygous mutations in congenital recessive ichthyosis |
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| modified | [InstanceEdit:5602968] Jassal, Bijay, 2014-06-25
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5633252] Matthews, Lisa, 2014-10-31
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635754] Matthews, Lisa, 2014-11-07
[InstanceEdit:5643915] Matthews, Lisa, 2014-11-19
[InstanceEdit:8940213] D'Eustachio, Peter, 2016-09-23
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Defective CYP4F22 does not 20-hydroxylate TrXA3 |
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| normalReaction |
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| releaseDate | 2014-12-11 |
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| reviewed | [InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:6781754] R-HSA-5602272.4 |
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| summation | [Summation:5602278] Cytochrome P450 4F22 (CYP4F22) is thought to 20-hydroxylate ... |
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| systematicName | CYP4F22 mutants do not hydroxylate TrXA3 |
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| (hasEvent) | [Pathway:5579005] Defective CYP4F22 causes ARCI5 [Homo sapiens] |
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| (updatedInstance) | [_UpdateTracker:9778125] Update Tracker - [FailedReaction:5602272] Defective CYP4F22 does not 20-hydroxylate TrXA3 - v68:[addCatalystActivity]
[_UpdateTracker:9782324] Update Tracker - [FailedReaction:5602272] Defective CYP4F22 does not 20-hydroxylate TrXA3 - v59:[add_removeLiteratureReference] |
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