Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Defective CYP2U1 does not omega-hydroxylate ARA

Class:IdFailedReaction:5602242
_displayNameDefective CYP2U1 does not omega-hydroxylate ARA
_doReleaseTRUE
_timestamp2014-11-20 02:48:04
authored[InstanceEdit:5602197] Jassal, Bijay, 2014-06-20
catalystActivity[CatalystActivity:9631874] monooxygenase activity of CYP2U1 mutants [endoplasmic reticulum membrane]
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:17957] endoplasmic reticulum lumen
created[InstanceEdit:5602246] Jassal, Bijay, 2014-06-20
disease[Disease:5602229] hereditary spastic paraplegia
edited[InstanceEdit:5602197] Jassal, Bijay, 2014-06-20
entityFunctionalStatus[EntityFunctionalStatus:5602256] loss_of_function of CYP2U1 mutants [endoplasmic reticulum membrane]
input[SimpleEntity:140356] AA [endoplasmic reticulum lumen]
[SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
[SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
[SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
isChimericFALSE
literatureReference[LiteratureReference:5602208] Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia
[LiteratureReference:5602244] Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms
modified[InstanceEdit:5602259] Jassal, Bijay, 2014-06-20
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5633252] Matthews, Lisa, 2014-10-31
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635754] Matthews, Lisa, 2014-11-07
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective CYP2U1 does not omega-hydroxylate ARA
normalReaction
releaseDate2014-12-11
reviewed[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644841] R-HSA-5602242.3
summation[Summation:5602202] Cytochrome P450 2U1 (CYP2U1) catalyses the hydroxylation of ...
systematicNameCYP2U1 mutants do not hydroxylate ARA
(hasEvent)[Pathway:5579011] Defective CYP2U1 causes SPG56 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778472] Update Tracker - [FailedReaction:5602242] Defective CYP2U1 does not omega-hydroxylate ARA - v68:[addCatalystActivity]
[Change default viewing format]
No pathways have been reviewed or authored by Defective CYP2U1 does not omega-hydroxylate ARA (5602242)
Follow Reactome