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Details on Person The second step in vitamin D3 activation requires hydroxylat...
| Class:Id | Summation:5602183 |
|---|---|
| _displayName | The second step in vitamin D3 activation requires hydroxylat... |
| _timestamp | 2014-09-08 17:21:47 |
| created | [InstanceEdit:5602197] Jassal, Bijay, 2014-06-20 |
| modified | [InstanceEdit:5622022] Jassal, Bijay, 2014-09-08 |
| text | The second step in vitamin D3 activation requires hydroxylation of 25-hydroxyvitamin D3 (calcidiol) to 1alpha-25-dihydroxyvitamin D3 (calcitriol). This conversion is mediated by 25-hydroxyvitamin D-1alpha hydroxylase (CYP27B1) (Zehnder et al. 2002, Fritsche et al. 2003). Defects in CYP27B1 can cause rickets, vitamin D-dependent 1A (VDDR1A; MIM:264700), a disorder caused by deficiency of the active form of vitamin D (CTL) resulting in defective bone mineralization and clinical features of rickets (Kim 2011). Mutations causing complete loss of function of CYP27B1 include R107H, G125E, R335P, P382S, R389G, R389H and D320Tfs*32 (Kitanaka et al. 1998, Wang et al. 2002, Wang et al. 1998). |
| (summation) | [FailedReaction:5602186] Defective CYP27B1 does not hydroxylate CDL [Homo sapiens] |
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