Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Defective CYP24A1 does not 24-hydroxylate CALTOL

Class:IdFailedReaction:5602004
_displayNameDefective CYP24A1 does not 24-hydroxylate CALTOL
_doReleaseTRUE
_timestamp2014-11-20 02:51:10
authored[InstanceEdit:5602016] Jassal, Bijay, 2014-06-16
catalystActivity[CatalystActivity:9631766] 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 mutants [mitochondrial inner membrane]
compartment[Compartment:5460] mitochondrial matrix
[Compartment:70616] mitochondrial inner membrane
created[InstanceEdit:5602016] Jassal, Bijay, 2014-06-16
disease[Disease:5602006] hypercalcemia
edited[InstanceEdit:5602016] Jassal, Bijay, 2014-06-16
entityFunctionalStatus[EntityFunctionalStatus:5602019] loss_of_function of CYP24A1 mutants [mitochondrial inner membrane]
input[SimpleEntity:215607] CTL [mitochondrial matrix]
[SimpleEntity:113600] NADPH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113533] O2 [mitochondrial matrix]
isChimericFALSE
literatureReference[LiteratureReference:5601999] Mutations in CYP24A1 and idiopathic infantile hypercalcemia
modified[InstanceEdit:5602024] Jassal, Bijay, 2014-06-16
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5633252] Matthews, Lisa, 2014-10-31
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635754] Matthews, Lisa, 2014-11-07
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective CYP24A1 does not 24-hydroxylate CALTOL
normalReaction
releaseDate2014-12-11
reviewed[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644960] R-HSA-5602004.3
summation[Summation:5601998] Catabolic inactivation of the active, hormonal form of vitam...
systematicNameCYP24A1 mutants do not hydroxylate CTL
(hasEvent)[Pathway:5579010] Defective CYP24A1 causes HCAI [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777969] Update Tracker - [FailedReaction:5602004] Defective CYP24A1 does not 24-hydroxylate CALTOL - v68:[addCatalystActivity]
[Change default viewing format]
No pathways have been reviewed or authored by Defective CYP24A1 does not 24-hydroxylate CALTOL (5602004)
Follow Reactome