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Details on Person Catabolic inactivation of the active, hormonal form of vitam...
| Class:Id | Summation:5601993 |
|---|---|
| _displayName | Catabolic inactivation of the active, hormonal form of vitam... |
| _timestamp | 2014-09-08 17:15:53 |
| created | [InstanceEdit:5602016] Jassal, Bijay, 2014-06-16 |
| modified | [InstanceEdit:5622022] Jassal, Bijay, 2014-09-08 |
| text | Catabolic inactivation of the active, hormonal form of vitamin D3 (calcitriol, CALTOL, 1,25-dihydroxyvitamin D3) is initially carried out by 24-hydroxylation, mediated by 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). The product formed is eventually transformed to calcitroic acid, the major water-soluble metabolite that can be excreted in bile. Defects in CYP24A1 can cause hypercalcemia infantile (HCAI; MIM:143880), a disorder characterised by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis (Schlingmann et al. 2011). |
| (summation) | [Pathway:5579010] Defective CYP24A1 causes HCAI [Homo sapiens] |
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No pathways have been reviewed or authored by Catabolic inactivation of the active, hormonal form of vitam... (5601993)
